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Jürgen Harder Selected Research

Ribonuclease 7

7/2021Expression of epidermal antimicrobial peptides is increased in tinea pedis.
1/2020Dysregulated Expression of Antimicrobial Peptides in Skin Lesions of Patients with Cutaneous T-cell Lymphoma.
1/2020RNase 7 Promotes Sensing of Self-DNA by Human Keratinocytes and Activates an Antiviral Immune Response.
1/2019The Antimicrobial and Immunomodulatory Function of RNase 7 in Skin.
1/2018RNase 7 Strongly Promotes TLR9-Mediated DNA Sensing by Human Plasmacytoid Dendritic Cells.
4/2016RNase 7 in Cutaneous Defense.
1/2014Infection of keratinocytes with Trichophytum rubrum induces epidermal growth factor-dependent RNase 7 and human beta-defensin-3 expression.
8/2013Prenatal human skin expresses the antimicrobial peptide RNase 7.
1/2013IL-17A and IFN-γ synergistically induce RNase 7 expression via STAT3 in primary keratinocytes.
1/2012Antimicrobial RNases in cutaneous defense.
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Jürgen Harder Research Topics

Disease

16Infections
10/2021 - 01/2005
11Atopic Dermatitis (Atopic Eczema)
05/2022 - 06/2007
10Wounds and Injuries (Trauma)
09/2021 - 02/2006
9Inflammation (Inflammations)
05/2022 - 02/2006
6Psoriasis (Pustulosis Palmaris et Plantaris)
01/2018 - 05/2010
5Neoplasms (Cancer)
11/2017 - 07/2006
4Skin Diseases (Skin Disease)
01/2019 - 05/2011
3Urinary Bladder Neoplasms (Bladder Cancer)
03/2008 - 07/2006
2Crohn Disease (Crohn's Disease)
02/2014 - 06/2007
2Infertility (Sterility)
08/2013 - 07/2011
2Bacterial Infections (Bacterial Infection)
10/2011 - 09/2002
1Pruritus (Itching)
05/2022
1Ileitis
11/2021
1Tinea Pedis (Athlete's Foot)
07/2021
1Starvation
12/2020
1Weight Gain
12/2020
1Anorexia Nervosa
12/2020
1Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous)
01/2020
1Herpes Simplex
01/2020
1Erysipelas
11/2014
1Soft Tissue Infections
11/2014
1Tinea (Ringworm)
01/2014
1Acne Vulgaris
06/2013
1Bacteremia
10/2012
1Varicose Ulcer (Ulcer, Venous)
07/2010
1Ulcer
07/2010
1Carcinoma (Carcinomatosis)
06/2010
1Necrosis
12/2008
1Cystic Fibrosis (Mucoviscidosis)
06/2007
1Skin Neoplasms (Skin Cancer)
04/2007
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
04/2007
1Basal Cell Carcinoma (Rodent Ulcer)
04/2007
1Mouth Neoplasms (Oral Cancer)
01/2007
1Squamous Cell Carcinoma of Head and Neck
01/2007
1Candidiasis (Moniliasis)
05/2005
1Invasive Candidiasis
05/2005
1Escherichia coli Infections
01/2005
1Persistent Infection
09/2002

Drug/Important Bio-Agent (IBA)

20Antimicrobial PeptidesIBA
11/2021 - 07/2006
14Adenosine Monophosphate (AMP)IBA
10/2021 - 02/2006
13Ribonuclease 7IBA
07/2021 - 05/2010
11S100 Calcium Binding Protein A7IBA
07/2021 - 01/2005
10Proteins (Proteins, Gene)FDA Link
09/2017 - 09/2002
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
09/2021 - 01/2017
5beta-DefensinsIBA
01/2020 - 09/2002
4DNA (Deoxyribonucleic Acid)IBA
10/2021 - 05/2011
3ChemokinesIBA
09/2021 - 08/2013
3CytokinesIBA
09/2021 - 05/2011
3ErbB Receptors (EGF Receptor)IBA
01/2016 - 08/2013
2Antiviral Agents (Antivirals)IBA
10/2021 - 01/2018
2Ribonucleases (Ribonuclease)IBA
01/2018 - 01/2012
2involucrinIBA
01/2017 - 04/2007
2DefensinsIBA
10/2013 - 05/2005
2CathelicidinsIBA
10/2013 - 05/2011
2Bromodeoxyuridine (BrdU)IBA
03/2008 - 07/2006
2Peptides (Polypeptides)IBA
03/2008 - 07/2006
1AntioxidantsIBA
05/2022
1X-Linked Inhibitor of Apoptosis ProteinIBA
11/2021
1S100 Proteins (S 100 Protein)IBA
07/2021
1EnzymesIBA
01/2020
1AllergensIBA
01/2018
1Protease Inhibitors (Protease Inhibitor)IBA
11/2017
1Transforming Growth Factors (Transforming Growth Factor)IBA
12/2016
1Intergenic DNA (Junk DNA)IBA
12/2016
1Interleukin-17 (Interleukin 17)IBA
02/2014
1Epidermal Growth Factor (EGF)IBA
01/2014
1RetinoidsIBA
06/2013
1Anti-Infective Agents (Microbicides)IBA
06/2013
1pimecrolimus (Elidel)FDA Link
10/2011
1Adrenal Cortex Hormones (Corticosteroids)IBA
10/2011
1Fatty Acids (Saturated Fatty Acids)IBA
10/2011
1InflammasomesIBA
05/2011
1Fura-2 (Fura 2)IBA
06/2010
1streptolysin OIBA
11/2009
1NF-kappa B (NF-kB)IBA
11/2009
1Virulence Factors (Pathogenicity Factors)IBA
11/2009
1Interleukin-1alpha (Interleukin 1 alpha)IBA
12/2008
1cecropin AIBA
03/2008
1CecropinsIBA
03/2008
1Messenger RNA (mRNA)IBA
04/2007
1Interleukin-8 (Interleukin 8)IBA
04/2007
1Antineoplastic Agents (Antineoplastics)IBA
01/2007
1Oxidoreductases (Dehydrogenase)IBA
07/2006
1MagaininsIBA
07/2006
1RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA
09/2002

Therapy/Procedure

5Therapeutics
01/2018 - 06/2013
1Skin Care
05/2022
1Precision Medicine
01/2020
1Surgical Amputation (Amputations)
09/2017